1 Nuclear Factor 1 and Metal Transcription Factor - 1 Synergistically Activate the Mouse Metallothionein - 1 Gene in Response to Metal Ions
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چکیده
NUCLEAR FACTOR 1 AND METAL TRANSCRIPTION FACTOR-1 SYNERGISTICALLY ACTIVATE THE MOUSE METALLOTHIONEIN-1 GENE IN RESPONSE TO METAL IONS* Olivier LaRochelle, Simon Labbé, Jean-François Harrisson, Carl Simard, Véronique Tremblay, Geneviève St-Gelais & Carl Séguin From Centre de recherche en cancérologie de l’Université Laval, CHUQ, Hôtel-Dieu de Québec, Québec (Québec) Canada G1R 2J6, and Département d’anatomie et de physiologie, Faculté de médecine, Université Laval, Québec (Québec) Canada G1K 7P4. Present address: Département de Biochimie, Faculté de médecine, Université de Sherbrooke, Sherbrooke, Québec (Québec) Canada, J1H 5N4. Running Title: NF-1 activates the mouse metallothionein-1 promoter Address correspondence to: Carl Séguin, Centre de recherche en cancérologie, Hôtel-Dieu de Québec, 11 côte du Palais, Québec (Québec) Canada G1R 2J6. Tel.: 418-525-4444, ext. 15544 ; Fax : 418-691-5439 ; e-mail : [email protected]
منابع مشابه
Nuclear factor-1 and metal transcription factor-1 synergistically activate the mouse metallothionein-1 gene in response to metal ions.
Metal activation of metallothionein (MT) gene transcription is dependent on the presence of metal regulatory elements (MREs), which are present in five non-identical copies (MREa through MREe) in the promoter of the mouse MT-1 gene and on the capacity of metal transcription factor-1 (MTF-1) to bind to the MREs in the presence of zinc. We detected a protein, distinct from MTF-1, specifically bin...
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